Which of the following is NOT part of the classic pentad of Thrombotic Thrombocytopenic Purpura?

• A. CNS abnormalities
• B. Renal disease
• C. Leukocytosis
• D. Fever

Answer: (C)

Thrombotic thrombocytopenic purpura is classically described by a pentad of findings: fever, neurologic abnormalities, renal dysfunction, thrombocytopenia, and microangiopathic hemolytic anemia. Leukocytosis is not among these defining features; white blood cell count is not a characteristic component of TTP’s presentation. The presence of fever, CNS symptoms, renal impairment, and evidence of hemolysis with low platelets points toward TTP rather than an isolated infectious or inflammatory process. Thus leukocytosis does not fit the classic pentad.