Which of the following is part of the classic pentad of Thrombotic Thrombocytopenic Purpura?

• A. CNS abnormalities
• B. Hyperglycemia
• C. Absent fever
• D. Increased platelets

Answer: (A)

Neurologic involvement is a recognized part of thrombotic thrombocytopenic purpura. The classic pentad includes microangiopathic hemolytic anemia, thrombocytopenia, neurologic symptoms, renal dysfunction, and fever. Brain involvement occurs because tiny clotting in small vessels can impair cerebral blood flow, leading to confusion, seizures, or other neuro deficits. That makes CNS abnormalities the correct option.

Hyperglycemia isn’t part of the pentad. Fever can be present but isn’t required in every case, and its absence isn’t defining. Increased platelets contradicts what happens in TTP, where platelets are depleted due to consumption in microthrombi.