Which analgesic should be avoided for pain in splenic rupture according to the material?

• A. Morphine
• B. Meperidine
• C. Hydromorphone
• D. Acetaminophen

Answer: (A)

In a patient with suspected splenic rupture, the goal is to relieve pain without compromising hemodynamic stability or masking signs of ongoing bleeding. Morphine is best avoided because it can cause histamine release, leading to vasodilation and a drop in blood pressure. In a bleeding trauma patient, this can worsen perfusion and make it harder to gauge how badly the patient is deteriorating. Other options listed tend to have less histamine-mediated hypotension, or provide safer non-opioid analgesia, making them preferable in this situation.