Tx for sickle cell crisis?

• A. Desmopressin; Platelets
• B. Oral rehydration; Opiates for pain; Oxygen
• C. Vitamin K; FFP
• D. Antibiotics only

Answer: (B)

In a sickle cell vaso-occlusive crisis, the priority is to relieve pain, restore hydration, and ensure adequate oxygen delivery. Hydration helps reduce blood viscosity, which improves microvascular flow and lowers the chance of further sickling. Providing analgesia with opioids addresses the typically intense pain of the crisis and decreases stress responses that can worsen vasoconstriction. Oxygen is given to maintain adequate oxygen saturation and prevent hypoxia, which can trigger or worsen sickling.

Other options don’t target these immediate needs. Desmopressin with platelets isn’t relevant to a vaso-occlusive crisis, and Vitamin K with FFP address coagulation issues rather than the crisis management. Antibiotics alone don’t treat the crisis’s pain and dehydration, though they’re considered if an infection is suspected.