The nonpitting, dry, waxy swelling of the skin seen in myxedema is referred to as what?

• A. Lymphedema
• B. Erythema
• C. Myxedema
• D. Dermatitis

Answer: (C)

This nonpitting, dry, waxy swelling is Myxedema. In severe hypothyroidism, mucopolysaccharides (glycosaminoglycans) accumulate in the dermis, pulling water into the interstitial space and producing a firm, doughy, nonpitting edema with a waxy texture and thickened skin. Erythema would be redness from inflammation, not a waxy edema. Dermatitis is inflammatory skin disease with itching and rash, not the characteristic waxy swelling. Lymphedema can be nonpitting but lacks the mucopolysaccharide-induced waxy texture seen in myxedema.