Intrinsic acute kidney injury is most commonly associated with which condition?

• A. Congestive heart failure
• B. Benign prostatic hypertrophy
• C. Septic shock
• D. NSAID overdose

Answer: (C)

Intrinsic acute kidney injury happens when the kidney itself is damaged, most often from ischemic injury to the tubules (acute tubular necrosis). In septic shock, severe hypotension and systemic inflammation cause profound renal hypoperfusion and direct tubular injury, making septic shock the scenario most classically linked to intrinsic AKI.

Congestive heart failure tends to cause a prerenal AKI from reduced renal perfusion rather than intrinsic tubular damage. Benign prostatic hyperplasia leads to postrenal obstruction, also not intrinsic. NSAID effects can contribute to kidney injury through altered renal hemodynamics or interstitial nephritis, but they are not the most common intrinsic AKI cause in typical practice.