How long should Plavix/Clopidogrel be used for drug-eluting stents?

• A. 3 months
• B. 6 months
• C. 9 months
• D. >=12 months

Answer: (D)

Ending endothelial healing after a drug-eluting stent leaves a risk of stent thrombosis that is mitigated by continuing dual antiplatelet therapy. Clopidogrel, with aspirin, is kept on for a prolonged period to cover the time when the stent is most vulnerable and healing is still incomplete. The standard minimum duration is 12 months of ongoing clopidogrel in combination with aspirin, assuming there are no major bleeding risks or other contraindications. Some patients with low bleeding risk may extend beyond a year, but 12 months or more is the commonly tested duration for DES.