A patient with salmonellosis is treated with which antibiotic?

• A. Ciprofloxacin
• B. Amoxicillin
• C. Metronidazole
• D. Azithromycin

Answer: (A)

When treating salmonellosis, antibiotics are reserved for invasive disease or patients at high risk, and the drug chosen should have strong activity against Salmonella with good tissue and intracellular penetration. Ciprofloxacin, a fluoroquinolone, fits this need well because it effectively targets Salmonella enterica and achieves good systemic concentrations, making it the preferred option in this context. Amoxicillin is less reliable due to common resistance among Salmonella strains. Metronidazole is active mainly against anaerobes and certain parasites, not Salmonella. Azithromycin can be an alternative in some cases, but ciprofloxacin remains the most appropriate first-line choice among these options for invasive Salmonella infection.